Short: Avoid Jet Lag
From all my time traveling, I've learned one major hack. If you fast the day of travel and eat once you land (at an appropriate meal time) you will not experience jet lag. That, unfortunately, means no airplane orange juice, nuts, biscuits, alcohol, or even sugar in your coffee. It seems like the hardest thing, but apart from preventing jet lag, it'll also keep you from having to use those questionable bathrooms.